EXPERT RESPONSE
Typically, this shouldn't cause any issues. The only way that I am aware of to clear this list is to recycle the Microsoft Exchange Information Store service … not something I'd recommend in production. So unless you're having specific issues, don't do anything. If you have issues, please write back with specifics.
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Related information from SearchExchange.com:
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Tip: Backing up, truncating and cleaning up Exchange transaction logs
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Tip: How to manually (and safely) purge Exchange Server transaction logs
Reference Center: Exchange Server monitoring and logging resources
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